Mystic Shot is a Tier 2 Weapon Item that grants increased Weapon Damage and Spirit Power. Its passive effect causes the next bullet fired to deal additional Spirit Damage.
The additional spirit damage occurs before the bullet damage. This is relevant for items such as Bullet Resist Shredder, since the spirit damage will activate the negative bullet resist effect, amplifying the bullet damage.
The bonus spirit damage is able to activate the Mystic Burst. However, this requires some additional spirit, since the base mystic shot damage is below the threshold to activate mystic burst. Similarly, mystic shot is able to activate the effect of Improved Burst, but requires significantly more spirit to get to the threshold spirit damage for activation.
1,250
5.2s
Bullet Resist Shredder, since the spirit damage will activate the negative bullet resist effect, amplifying the bullet damage.
Mystic Burst. However, this requires some additional spirit, since the base mystic shot damage is below the threshold to activate mystic burst. Similarly, mystic shot is able to activate the effect of 
Improved Burst, but requires significantly more spirit to get to the threshold spirit damage for activation.
